Publications

HeartDyno® Platform

1. 🎉 Maturation of human cardiac organoids enables complex disease modelling and drug discovery.
   ‍Pocock, M. et al. pre-print (2024). Link
2. Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.
   Mills, R. J. et al. Cell Stem Cell 24, 895-907.e6 (2019). Link
3. Development of a human cardiac organoid injury model reveals innate regenerative potential.
   Voges, H. K. et al. Development 144, 1118–1127 (2017). Link
4. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
   Mills, R. J. et al. PNAS 24, 114, E8372–E8381 (2017). Link

Disease Models

1. Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle.
   McNamara, J. W. et al., Nature Cardiovasc Res 2 159–173 (2023).  Link
2. Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease.
   Mellor, K. M. et al., Nature Cardiovasc Res 2 159–173 (2023). Link
3. BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection.
   Mills, R. J. et al. Cell, 1, (2021). Link

Omics

• Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy
  Mehdiabadi, N. R. et al., Circulation 146, 1105–1108 (2022). Link
• Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor
  Sim, C. B. et al., Circulation, 143, 1614–1628 (2021). Link
• Multicellular Transcriptional Analysis of Mammalian Heart Regeneration.
  Quaife-Ryan G. A. et al. Circulation 136, 1123–1139 (2017). Link