🎉 Maturation of human cardiac organoids enables complex disease modelling and drug discovery. Pocock, M. et al. pre-print (2024). Link
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway. Mills, R. J. et al. Cell Stem Cell 24, 895-907.e6 (2019). Link
Development of a human cardiac organoid injury model reveals innate regenerative potential. Voges, H. K. et al. Development 144, 1118–1127 (2017). Link
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest Mills, R. J. et al. PNAS 24, 114, E8372–E8381 (2017). Link
Disease Models
Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. McNamara, J. W. et al., Nature Cardiovasc Res 2 159–173 (2023). Link
Protective role of the Atg8 homologue Gabarapl1 in regulating cardiomyocyte glycophagy in diabetic heart disease. Mellor, K. M. et al., Nature Cardiovasc Res 2 159–173 (2023). Link
BET Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection. Mills, R. J. et al. Cell, 1, (2021). Link
Omics
Defining the Fetal Gene Program at Single-Cell Resolution in Pediatric Dilated Cardiomyopathy Mehdiabadi, N. R. et al., Circulation 146, 1105–1108 (2022). Link
Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor Sim, C. B. et al., Circulation, 143, 1614–1628 (2021). Link
Multicellular Transcriptional Analysis of Mammalian Heart Regeneration. Quaife-Ryan G. A. et al. Circulation 136, 1123–1139 (2017). Link
